PCI vs. CABG in the Treatment of Unprotected Left Main Stenosis (LeftMain/NOBLE)
The NOBLE trial
NOBLE
To investigate Coronary Artery Bypass Grafting Versus Drug Eluting Stent Percutaneous Coronary Angioplasty in the Treatment of Unprotected Left Main Stenosis in a clinical, randomized 5 year follow-up trial.
Trial period
•
2008 - 2025
Status
•
Complete
Inclusions
•
1201 Complete
Centers
•
36
Countries
•
9
Publications
•
6
MEDIA
PUBLICATIONS
Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial
Holck Emil Nielsen, Holm Niels R, Hildick-Smith David, Lindsay M Mitchell, Spence Mark S, +18 more
Percutaneous Coronary Intervention vs Coronary Artery Bypass Graft Surgery for Left Main Disease in Patients with and Without Acute Coronary Syndromes: A Pooled Analysis of 4 Randomized Clinical Trials
Gaba Prakriti, Christiansen Evald H., Nielsen Per H., Murphy Sabina A., O’Gara Patrick T., +10 more
Intravascular ultrasound to guide left main stem intervention: A NOBLE trial substudy
Ladwiniec Andrew, Walsh Simon J., Holm Niels Ramsing, Hanratty Colm G., Mäkikallio Timo, +10 more
Percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial
Holm Niels R, Mäkikallio Timo, Lindsay M Mitchell, Spence Mark S, Erglis Andrejs, +63 more
Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial
Mäkikallio Timo, Holm Niels R, Lindsay Mitchell, Spence Mark S, Erglis Andrejs, +40 more
The EXCEL and NOBLE trials: similarities, contrasts and future perspectives for left main revascularisation.
Campos Carlos M., Christiansen Evald H., Stone Gregg W., Serruys Patrick W.,